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Among many primate species harboring endemic SIVs, there is a notable absence of pathogenesis. Comparative genome analysis also provides information about epitopes on surface and secreted proteins that may be evolutionary constrained and hence viable targets for vaccine or immunologically targeted therapies.

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Abstract the following series of concise summaries addresses the evolution of infectious agents in relation to sex in animals and humans from the perspective of three specific questions: 1 what have we learned about the likely origin and phylogeny, up to the establishment of the infectious agent in the genital econiche, including the relative frequency of its sexual transmission; 2 what further research is needed to provide additional knowledge on some of these evolutionary aspects; and 3 what evolutionary considerations might aid in providing novel approaches to the more practical clinical and public health issues facing us currently and in the future?

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